<i>Lactobacillus plantarum</i> CCFM1180 attenuates obesity induced by oestrogen deficiency by activating oestrogen receptor alpha in abdominal adipose tissue and regulating gut microbiota-derived metabolites

Lipid metabolism disorders commonly occur during menopause. Estrogen deficiency has been shown to lead excessive energy intake and abnormal lipid in ovariectomized rats, resulting obesity. Probiotics exhibit anti-obesity properties, their underlying mechanism widely reported. In this study, we demonstrated the metabolic benefits of Lactobacillus plantarum CCFM1180 suppressing appetite, controlling body weight, correcting obesity-induced abnormalities, enhancing liver metabolism, protecting function estrogen-deficient rats. The mechanisms associated with anti-dyslipidemia effects on rats were clarified. results showed that dramatically reduced food by activating expression estrogen receptor alpha (ERα) increasing level leptin abdominal adipose tissue. These changes, combined increased butyrate concentration recovered bile acid structure, helped enhance metabolism. Additionally, treatment was found be safer than exogenous supplementation. Thus, L. could considered a new therapeutic strategy for preventing alleviating menopausal abnormalities.